Table 2.
Significantly altered metabolites and key discriminants of biochemical changes in adenocarcinoma compared to non-malignant tissue.
| Name | Fold changea |
Directionb | pFDRc | Rankd |
|---|---|---|---|---|
| Amino Acids and Derivatives | ||||
| ornithine | 0.5 | DOWN | 9.61E-06 | 2 |
| citrulline | 0.7 | DOWN | 0.003944 | 4 |
| lysine | 0.4 | DOWN | 6.49E-05 | 5 |
| cysteine | 1.6 | UP | 0.002516 | 6 |
| spermidine | 0.7 | DOWN | 0.001625 | 8 |
| glutamate | 1.4 | UP | 0.001694 | 12 |
| trans-4-hydroxyproline | 1.3 | UP | 0.007531 | |
| proline | 1.4 | UP | 0.008061 | |
| methionine sulfoxide | 0.6 | DOWN | 0.045096 | |
| isothreonic acid | 1.3 | UP | 0.007637 | |
| glyceric acid | 1.4 | UP | 0.017117 | |
| alanine | 1.2 | UP | 0.013497 | |
| histidine | 0.6 | DOWN | 0.012104 | |
| Organic Acids | ||||
| 4-hydroxybutyric acid | 1.3 | UP | 0.004333 | 9 |
| malic acid | 1.3 | UP | 0.045285 | |
| citric acid | 0.6 | DOWN | 0.007308 | |
| 2-hydroxyglutaric acid | 1.7 | UP | 0.003292 | |
| Carbohydrates and Related Compounds | ||||
| ribitol | 1.8 | UP | 6.64E-07 | 3 |
| glucose | 0.5 | DOWN | 0.000366 | 16 |
| Fucose + rhamnose | 2.1 | UP | 0.000177 | 18 |
| arabitol | 1.4 | UP | 0.003463 | 20 |
| xylitol | 1.4 | UP | 0.000939 | |
| tagatose | 0.8 | DOWN | 0.022467 | |
| mannitol | 0.7 | DOWN | 0.016961 | |
| glycerol-3-galactoside | 2.2 | UP | 0.003224 | |
| glycerol | 1.2 | UP | 0.018636 | |
| fucose | 1.5 | UP | 0.007527 | |
| erythronic acid lactone | 0.6 | DOWN | 0.006205 | |
| erythronic acid | 1.2 | UP | 0.048138 | |
| arabinose | 1.3 | UP | 0.000454 | |
| 1,5-anhydroglucitol | 0.8 | DOWN | 0.037117 | |
| Monoglycerols | ||||
| 1-monopalmitin | 1.1 | UP | 0.047396 | |
| 1-monostearin | 0.8 | DOWN | 0.047268 | 11 |
| Tocopherols | ||||
| alpha-tocopherol | 2.2 | UP | 4.12E-07 | 13 |
| gamma-tocopherol | 1.2 | UP | 0.010335 | |
| Fatty Acids | ||||
| arachidonic acid | 1.5 | UP | 0.006889 | |
| capric acid | 0.8 | DOWN | 0.004333 | |
| caprylic acid | 0.8 | DOWN | 0.001644 | 19 |
| lauric acid | 0.9 | DOWN | 0.034948 | |
| palmitic acid | 0.9 | DOWN | 0.027453 | |
| pelargonic acid | 0.8 | DOWN | 0.033083 | |
| pentadecanoic acid | 0.8 | DOWN | 0.014977 | |
| stearic acid | 0.8 | DOWN | 0.047396 | |
| Miscellaneous Lipids | ||||
| dihydrosphingosine | 0.6 | DOWN | 0.000544 | |
| dodecanol | 0.8 | DOWN | 0.00205 | |
| gluconic acid | 0.5 | DOWN | 0.000381 | |
| triethanolamine | 0.7 | DOWN | 0.002243 | |
| 3-phosphoglycerate | 0.4 | DOWN | 0.001049 | |
| Purines and Pyrimidines | ||||
| 5,6-dihydrouracil | 2.4 | UP | 2.42E-07 | 1 |
| xanthine | 2.7 | UP | 0.000381 | 10 |
| 5'-deoxy-5'-methylthioadenosine | 1.8 | UP | 6.49E-05 | 14 |
| adenine | 1.5 | UP | 0.000366 | 15 |
| adenosine-5-phosphate | 2.5 | UP | 0.00132 | 17 |
| uridine | 0.7 | DOWN | 0.002044 | |
| uracil | 1.4 | UP | 0.036508 | |
| inositol-4-monophosphate | 0.7 | DOWN | 0.020452 | |
| inosine 5'-monophosphate | 3.5 | UP | 0.00085 | |
| cytidine-5-monophosphate | 1.8 | UP | 0.001397 | |
| allantoic acid | 0.6 | DOWN | 0.005247 | |
| Miscellaneous Metabolites | ||||
| UDP GlcNAc | 2.3 | UP | 2.24E-05 | 7 |
| uric acid | 1.4 | UP | 0.019398 | |
| UDP-glucuronic acid | 1.2 | UP | 0.00667 | |
| quinic acid | 0.8 | DOWN | 0.020487 | |
| nicotinamide | 1.4 | UP | 0.006078 | |
| N-acetyl-D-mannosamine | 1.5 | UP | 0.000333 | |
| hydroxylamine | 0.8 | DOWN | 0.013145 | |
| creatinine | 1.4 | UP | 0.01111 | |
| biuret | 0.6 | DOWN | 0.002136 | |
| benzoic acid | 0.9 | DOWN | 0.038501 | |
| aminomalonic acid | 1.3 | UP | 0.030249 | |
a
ratio of means relative to control
b
direction of change in means relative to control
c
false discovery rate adjusted mixed effects model p-value
d
importance of metabolic change based on O-PLS-DA model loading