Table 2.
Name | Fold changea |
Directionb | pFDRc | Rankd |
---|---|---|---|---|
Amino Acids and Derivatives | ||||
ornithine | 0.5 | DOWN | 9.61E-06 | 2 |
citrulline | 0.7 | DOWN | 0.003944 | 4 |
lysine | 0.4 | DOWN | 6.49E-05 | 5 |
cysteine | 1.6 | UP | 0.002516 | 6 |
spermidine | 0.7 | DOWN | 0.001625 | 8 |
glutamate | 1.4 | UP | 0.001694 | 12 |
trans-4-hydroxyproline | 1.3 | UP | 0.007531 | |
proline | 1.4 | UP | 0.008061 | |
methionine sulfoxide | 0.6 | DOWN | 0.045096 | |
isothreonic acid | 1.3 | UP | 0.007637 | |
glyceric acid | 1.4 | UP | 0.017117 | |
alanine | 1.2 | UP | 0.013497 | |
histidine | 0.6 | DOWN | 0.012104 | |
Organic Acids | ||||
4-hydroxybutyric acid | 1.3 | UP | 0.004333 | 9 |
malic acid | 1.3 | UP | 0.045285 | |
citric acid | 0.6 | DOWN | 0.007308 | |
2-hydroxyglutaric acid | 1.7 | UP | 0.003292 | |
Carbohydrates and Related Compounds | ||||
ribitol | 1.8 | UP | 6.64E-07 | 3 |
glucose | 0.5 | DOWN | 0.000366 | 16 |
Fucose + rhamnose | 2.1 | UP | 0.000177 | 18 |
arabitol | 1.4 | UP | 0.003463 | 20 |
xylitol | 1.4 | UP | 0.000939 | |
tagatose | 0.8 | DOWN | 0.022467 | |
mannitol | 0.7 | DOWN | 0.016961 | |
glycerol-3-galactoside | 2.2 | UP | 0.003224 | |
glycerol | 1.2 | UP | 0.018636 | |
fucose | 1.5 | UP | 0.007527 | |
erythronic acid lactone | 0.6 | DOWN | 0.006205 | |
erythronic acid | 1.2 | UP | 0.048138 | |
arabinose | 1.3 | UP | 0.000454 | |
1,5-anhydroglucitol | 0.8 | DOWN | 0.037117 | |
Monoglycerols | ||||
1-monopalmitin | 1.1 | UP | 0.047396 | |
1-monostearin | 0.8 | DOWN | 0.047268 | 11 |
Tocopherols | ||||
alpha-tocopherol | 2.2 | UP | 4.12E-07 | 13 |
gamma-tocopherol | 1.2 | UP | 0.010335 | |
Fatty Acids | ||||
arachidonic acid | 1.5 | UP | 0.006889 | |
capric acid | 0.8 | DOWN | 0.004333 | |
caprylic acid | 0.8 | DOWN | 0.001644 | 19 |
lauric acid | 0.9 | DOWN | 0.034948 | |
palmitic acid | 0.9 | DOWN | 0.027453 | |
pelargonic acid | 0.8 | DOWN | 0.033083 | |
pentadecanoic acid | 0.8 | DOWN | 0.014977 | |
stearic acid | 0.8 | DOWN | 0.047396 | |
Miscellaneous Lipids | ||||
dihydrosphingosine | 0.6 | DOWN | 0.000544 | |
dodecanol | 0.8 | DOWN | 0.00205 | |
gluconic acid | 0.5 | DOWN | 0.000381 | |
triethanolamine | 0.7 | DOWN | 0.002243 | |
3-phosphoglycerate | 0.4 | DOWN | 0.001049 | |
Purines and Pyrimidines | ||||
5,6-dihydrouracil | 2.4 | UP | 2.42E-07 | 1 |
xanthine | 2.7 | UP | 0.000381 | 10 |
5'-deoxy-5'-methylthioadenosine | 1.8 | UP | 6.49E-05 | 14 |
adenine | 1.5 | UP | 0.000366 | 15 |
adenosine-5-phosphate | 2.5 | UP | 0.00132 | 17 |
uridine | 0.7 | DOWN | 0.002044 | |
uracil | 1.4 | UP | 0.036508 | |
inositol-4-monophosphate | 0.7 | DOWN | 0.020452 | |
inosine 5'-monophosphate | 3.5 | UP | 0.00085 | |
cytidine-5-monophosphate | 1.8 | UP | 0.001397 | |
allantoic acid | 0.6 | DOWN | 0.005247 | |
Miscellaneous Metabolites | ||||
UDP GlcNAc | 2.3 | UP | 2.24E-05 | 7 |
uric acid | 1.4 | UP | 0.019398 | |
UDP-glucuronic acid | 1.2 | UP | 0.00667 | |
quinic acid | 0.8 | DOWN | 0.020487 | |
nicotinamide | 1.4 | UP | 0.006078 | |
N-acetyl-D-mannosamine | 1.5 | UP | 0.000333 | |
hydroxylamine | 0.8 | DOWN | 0.013145 | |
creatinine | 1.4 | UP | 0.01111 | |
biuret | 0.6 | DOWN | 0.002136 | |
benzoic acid | 0.9 | DOWN | 0.038501 | |
aminomalonic acid | 1.3 | UP | 0.030249 |
ratio of means relative to control
direction of change in means relative to control
false discovery rate adjusted mixed effects model p-value
importance of metabolic change based on O-PLS-DA model loading