Table 4.
Delivery characteristics and initial neonatal outcomes
| Variable | Tocolysis N=233 |
No Tocolysis N=64 |
p-value |
|---|---|---|---|
| Mean delivery gestational age (weeks) | 28.9 +/− 2.7 | 29.2 +/− 2.7 | 0.408 |
| Mean admission-to-delivery interval (days) | 1.8 +/− 4.3 | 1.2 +/− 4.9 | 0.326 |
| Pregnant for ≥48 hours after admission (n, %) | 55 (23.6) | 5 (7.8) | 0.005 |
| Pregnant for ≥7 days after admission (n, %) | 12 (5.2) | 3 (4.7) | 0.881 |
| Delivered ≥ 34.0 weeks gestation (n, %) | 4 (1.7) | 0 (0) | 0.291 |
| Delivered ≥ 37.0 weeks gestation (n, %) | 0 | 0 | - |
| Cesarean section (n, %) | 60 (25.8) | 21 (32.8) | 0.261 |
| Diagnosis of clinical chorioamnionitis (n, %) | 33 (14.2) | 7 (10.9) | 0.503 |
| Acute chorioamnionitis or funisitis on placental pathology* | 79/168 (47.0) | 18/49 (36.7) | 0.202 |
| Postpartum endometritis [in the absence of previous diagnosis of chorioamnionitis, (n, %)] | 4 (1.7) | 2 (3.1) | 0.478 |
| Median maternal length of stay (days, IQR) | 2 (2–5) | 2 (1–3) | 0.206 |
| Male infant (n, %) | 133 (57.1) | 37 (57.8) | 0.917 |
| Mean birthweight (grams) | 1357 +/− 491 | 1468 +/− 499 | 0.113 |
| Admission to neonatal intensive care unit (n, %) | 219 (94.0) | 56 (87.5) | 0.079 |
| Neonate transferred within 24 hours of birth to other facility for higher level of care | 10 (4.3) | 8 (12.5) | 0.015 |
| Major neonatal morbidity † | 97 (41.6) | 28 (43.8) | 0.761 |
| Neonatal death (n, %) | 19 (8.2) | 7 (10.9) | 0.485 |
| Intraventricular hemorrhage grade I or II (n, %) | 40 (17.2) | 7 (10.9) | 0.226 |
| Intraventricular hemorrhage grade III or IV (n, %) | 28 (12.0) | 11 (17.2) | 0.278 |
| Periventricular leukomalacia (n, %) | 11 (4.7) | 3 (4.7) | 0.991 |
| Neonatal bronchopulmonary dysplasia (n, %) | 60 (25.8) | 18 (28.1) | 0.702 |
| Neonatal respiratory distress (n, %) | 220 (94.4) | 54 (84.4) | 0.005 |
| Need for intubation (n, %) | 162 (69.5) | 39 (60.9) | 0.193 |
| Median days intubated (IQR) ‡ | 1 (0 – 10) | 2 (1 – 5) | 0.385 |
| Neonatal necrotizing enterocolitis (n, %) | 23 (9.9) | 5 (7.8) | 0.618 |
| Neonatal sepsis (culture proven) | 34 (14.6) | 7 (10.9) | 0.453 |
| Median neonatal length of stay (days, IQR) § | 42 (27–73) | 36 (14–59) | 0.080 |
*
placental pathology available for 217 pregnancies
†
defined as the diagnosis of at least one of the following prior to discharge: bronchopulmonary dysplasia, grade III or IV intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, stillbirth or neonatal death
‡
among 201 intubated neonates
§
among neonates admitted to the neonatal intensive care unit