Fig. 8.

Effects of decreasing GF bioavailability. a Decreased GF production causes a delay in regeneration. b As GFs become less available, c fewer hepatocytes enter the cell cycle, decreasing peak of regenerating cells. The synchronicity of hepatocyte entry into the cell cycle, however, is affected only slightly. d-e To decrease the synchronicity of entry into the cell cycle, it is necessary to decrease the proliferation rate