Table 2.
Summary of parameters used to simulate alternate hypotheses of how human liver regeneration differs from rat liver regeneration
| Hyp 1: Altered cytokine response | Hyp 2:Altered GF storage and ECM balance | Hyp 3: Altered state transition rate | Hyp 4: From Periwal et al. [29] | Hyp 5: Reduced metabolic demand |
|---|---|---|---|---|
| kIL6 = 0.1435 | κdeg = 4.955 | kQP = 1.4x10−3 | kQP = 1.1x10−3 | M = 20.8217 |
| κIL6 = 0.4942 | κECM = 56.30 | kPR = 1.5x10−3 | kPR = 2.6x10−3 | G = 3.474x10−4 |
| VJAK = 1.364x103 | kGF = 3.288x10−3 | kRQ = 70.9x10−3 | kRQ = 135x10−3 | |
| Km JAK = 7.565x103 | κGF = 2.139x10−3 | kreq = 4.17x10−3 | ||
| κJAK = 0.0398 | kup = 0.1008 | kap = 4.17x10−3 | ||
| [STAT3] = 2.031 | kprol = 8.33x10−3 | |||
| kSTAT3 = 1.109x103 | ||||
| Km STAT = 0.5178 | ||||
| κSOCS = 0.1682 | ||||
| KI SOCS3 = 0.0569 | ||||
| kIE = 18.60 | ||||
| Km IE = 88.13 | ||||
| κIE = 1.148 |