Table 2.
Univariable and multivariable analysis of the association between preoperative risk biochemical recurrence in patients with adverse pathology*
| Adverse feature (low-risk vs intermediate- and high-risk patients) |
Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| ECE | 0.29 (0.21–0.40) | <0.0001 | 0.51 (0.36–0.72) | 0.0001 |
| SVI | 0.70 (0.37–1.32) | 0.3 | 0.68 (0.35–1.31) | 0.2 |
| Pathologic Gleason ≥7 | 0.26(0.20–0.34) | <0.0001 | 0.45 (0.35–0.60) | <0.0001 |
| LNI | 0.53 (0.22–1.29) | 0.2 | 0.44 (0.18–1.08) | 0.073 |
| Positive surgical margins | 0.38 (0.26–0.54) | <0.0001 | 0.76 (0.50–1.14) | 0.2 |
CI = confidence interval; ECE = extracapsular extension; HR = hazard ratio; LNI = lymph node invasion; SVI = seminal vesical invasion.
*
For example, the HR of 0.29 for ECE means that, among men with ECE, the risk of recurrence was about two-thirds lower in men who had preoperative low-risk features in comparison with men with preoperative intermediate- or high-risk disease.