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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Aug 25;8(5):707–716. doi: 10.1161/CIRCGENETICS.115.001097

Figure 5.

Figure 5

AHRR expression associations with AHRR methylation and carotid plaque score. (a) mRNA expression profiles of AHRR measured using RNA sequencing (y-axis, normalized values) negatively correlate (r = −0.42, p = 1.36×10−17) with methylation of AHRR cg05575921 (x-axis, beta-value) measured using the Illumina 450K microarray. Regression covariates included age, sex, race, and study site. (b) Forest plot shows the estimated effect size (x-axis: beta and 95% CI) of AHRR mRNA expression on carotid plaque score (overall and stratified by smoking status). Also shown are the sample size (n), the partial Pearson’s correlation coefficient (Cor) between AHRR expression and carotid plaque score, the unique variance of carotid plaque score explained by AHRR expression (Rsq), and the significance (Pval). Regression covariates included age, sex, race, BMI, LDL cholesterol, diabetes, and hypertension.