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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Cell. 2011 Sep 30;147(1):44–56. doi: 10.1016/j.cell.2011.09.009

Figure 5. A Metagenetic View of Developing Normal and Pathological Immune Responses.

Figure 5

This flow-chart depicts stages in the development of normal immune responses or auto-immune and inflammatory diseases at which metagenetic interactions (i.e., gene-gene and gene-microbe interactions) might play a determining role. 'Microbial products' refers to molecules that interact with host innate immune sensors and initiate inflammation.