Table 1.
Summary of lncRNA analyzed by several biochemistry approaches
| LncRNAs | RBP | Biological function | Methods | Ref |
|---|---|---|---|---|
| ANRIL | PCR2, PCR1 | Influences p16 INK4a gene expression and cell senescence | CLIP | [38] |
| Air | G9a | Targets G9a in cis for imprinting | CLIP | [57] |
| Fendrr | PRC2, WDR5 | Regulates gene in cis and in trans | RIP | [29] |
| FIRRE | hnPNPU | Modulation of nuclear architecture across chromosomes | RAP | [58] |
| HOTAIR | PCR2, LSD1 | Silences transcription in trans via its modular architecture | RNA pull-down | [37] |
| Hottip | MLL-WDR5 | Activates gene expression via chromosomal looping | RIP | [59] |
| lincRNA-p21 | hnRNP-K | Mediates p53-dependent gene repression | RNA pull down-MS | [31] |
| MALAT1 | PSPC1, PSF, PURA | Sequesters splicing factor to regulate alternative splicing | CHART-MS | [60] |
| NEAT1 | PSPC1, SRSF1, ESRP2 | Plays roles in RNA processing and transcriptional regulation | CHART-MS | [60] |
| Rox1 | MLE, MSL | Mediates X chromosome upregulated to rescue male lethality | dChIRP | [61] |
| TERC | TCAB1 | Functions as the template and scaffold for the telomerase complex | ChIRP | [47] |
| Xist | 81 proteins (Hnrnpk, Spen) | Mediates chromatin modifications and Polycomb targeting | ChIRP-MS | [62] |
| Xist | 10 proteins (SHARP, HDAC3) | Interacts directly with SHARP to silence transcription through HDAC3 | RAP-MS | [63] |