Additional file 2: Nervous syndrome. Steer P90-2 presenting with the nervous syndrome at 24 months after intracerebral inoculation with the post-1990 scrapie pool; TSE confirmed by postmortem tests. This steer displays an abnormal rising behaviour (attempt to rise on its fore limbs first when disturbed by a pen mate). Examination in a crush reveals over-reactivity to visual (menace response testing) and tactile facial stimuli (testing of sensation by touch with artery forceps) as well as tremor of the shoulder muscles. It is reluctant to walk towards the end of the corridor, seemingly apprehensive of the drain cover and groove on the floor, which it does not want to cross. There is mild hind limb ataxia as the steer walks away. Back in the pen, the steer is apprehensive of the approaching hand, tossing its head and wrinkling its nose before backing off, unlike the other steers in the pen, which appear curious.
Download video file (8MB, mov)