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. 2015 Oct 20;11(10):e1005177. doi: 10.1371/journal.ppat.1005177

Fig 5. CD39 is highly up-regulated by exhausted CD8+ T cells in a mouse model of chronic infection.

Fig 5

(A, B) Expression of CD39 and PD-1 by CD44– naive mouse CD8+ T cells (A) and in CD8+ T cells at indicated times following LCMV Armstrong (acute) or Clone 13 (chronic) infection (B). Representative plots show total (black) and H-2Db GP276-286 tetramer-specific CD8+ T cells (red). Summary of results in 5 mice per group is shown in bar-graphs on the right. Statistical significance was assessed with Mann-Whitney test. *P < 0.5, **P < 0.01.