Table 2. Summary of Association with the Risk of PAD.
dbSNP ID | Chr. | Gene | Phase | Number of samples | MAF | OR | 95%CI | P | ||
---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | |||||||
rs9584669 | 13 | IPO5/RAP2A | GWAS | 785 | 3383 | 0.04 | 0.06 | 0.60 | 0.45–0.79 | 2.76 x 10−4 |
Replication | 2379 | 16751 | 0.03 | 0.05 | 0.57 | 0.48–0.66 | 2.10 x 10−11 | |||
Combined* | 3164 | 20134 | 0.03 | 0.05 | 0.58 | 0.50–0.66 | 6.78 x 10−14 | |||
rs6842241 | 4 | EDNRA | GWAS | 785 | 3372 | 0.36 | 0.30 | 0.76 | 0.68–0.85 | 2.36 x 10−6 |
Replication | 2342 | 16750 | 0.33 | 0.30 | 0.88 | 0.83–0.93 | 9.09 x 10−5 | |||
Combined* | 3127 | 20122 | 0.34 | 0.30 | 0.85 | 0.80–0.90 | 5.32 x 10−9 | |||
rs2074633 | 7 | HDAC9 | GWAS | 785 | 3382 | 0.43 | 0.38 | 1.24 | 1.11–1.38 | 1.41 x 10−4 |
Replication | 2363 | 16751 | 0.41 | 0.38 | 1.13 | 1.06–1.20 | 7.63 x 10−5 | |||
Combined* | 3148 | 20133 | 0.41 | 0.38 | 1.16 | 1.10–1.22 | 8.43x 10−8 |
ID; identifier, Chr.; chromosome, MAF; minor allele frequency, OR; odds ratio, CI; confidence interval.
*; P value was calculated by Mantel-Haenszel test.