Table 3.

Univariate Cox proportional hazards models for risk factors for DSA, CLAD, and graft failure.

Variable	DSA			CLAD			Graft failure
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
Male recipient	1.06	0.77–1.46	0.72	0.96	0.69–1.34	0.83	0.99	0.69–1.42	0.97
Recipient age	0.99	0.99–1.01	0.36	1.00	0.99–1.01	0.87	0.99	0.98–1.01	0.27
Diagnosis (reference: COPD)			0.99			0.87			0.26
Cystic fibrosis	1.15	0.72–1.82	0.55	0.87	0.53–1.41	0.57	1.10	0.67–1.81	0.70
Interstitial lung disease	1.10	0.73–1.63	0.66	0.92	0.61–1.37	0.68	0.70	0.44–1.09	0.12
Re-transplant	0.97	0.43–2.17	0.94	0.63	0.25–1.60	0.33	0.63	0.22–1.77	0.38
Pulmonary hypertension	1.61	0.22–11.7	0.64	1.11	0.15–8.19	0.91	2.13	0.51–8.85	0.30
Other	1.12	0.59–2.14	0.73	0.71	0.35–1.43	0.34	1.08	0.56–2.07	0.83
Allosensitized pre-transplant	1.11	0.80–1.54	0.53	1.04	0.74–1.47	0.82	1.06	0.73–1.54	0.78
Pre-transplant CPRA	1.00	0.99–1.01	0.65	0.99	0.99–1.01	0.56	0.99	0.99–1.01	0.79
Number of pre-transplant HLA antibodies	0.99	0.96–1.03	0.67	0.99	0.95–1.02	0.60	0.99	0.94–1.03	0.59
Pre-transplant HLA antibody class			0.67			0.76			0.66
Class I only	1.14	0.76–1.71	0.52	1.16	0.78–1.74	0.46	0.89	0.55–1.45	0.64
Class II only	0.83	0.42–1.64	0.59	0.78	0.38–1.61	0.50	1.28	0.66–2.48	0.46
Class I and II	1.27	0.76–2.13	0.36	0.98	0.52–1.83	0.94	1.31	0.69–2.46	0.41
Positive direct crossmatch	0.99	0.57–1.73	0.98	0.95	0.52–1.71	0.85	1.28	0.72–2.28	0.40
PGD 3 at 72 hours	2.50	1.16–5.38	0.02	1.97	0.94–4.14	0.07	2.06	0.92–4.62	0.08
DSA*				1.55	1.11–2.16	0.01	2.06	1.41–3.00	<0.001
Acute rejection grade ≥ A2*	1.86	1.25–2.76	0.002	1.11	0.79–1.55	0.55	0.95	0.65–1.38	0.77
Lymphocytic bronchiolitis ≥ B1R*	1.27	0.86–1.87	0.23	0.93	0.66–1.30	0.67	0.99	0.68–1.45	0.98
CARV infection*	0.17	0.02–1.25	0.10	1.46	0.91–2.36	0.12	1.19	0.70–2.02	0.52
CLAD*	4.59	2.02–10.4	<0.001				8.92	5.61–14.2	<0.001

^*Analyzed as a time-dependent variable