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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Dev Dyn. 2015 Sep 2;244(11):1439–1455. doi: 10.1002/dvdy.24322

Figure 6.

Figure 6

Reduced and mispatterned differentiation of photoreceptors in cloche mutant embryos. A-B. Immunofluorescence images of 72 hpf retinas of wild-type (A) and clo−/− (B) embryos stained with the 1D1 antibody, detecting rod photoreceptors. C-D. Immunofluorescence images of 72 hpf retinas of wild-type (D) and clo−/− (E) embryos stained with the ZPR1 antibody, detecting cone photoreceptors. Arrows in D show developing cones flanking a region of the ONL that is not ZPR1+. E. Numbers of 1D1+ cells are significantly (***, p<0.001) reduced in clo−/− retinas. F. The extent of ZPR1 labeling (F) and the distribution of ZPR1+ cells (F‘) is also significantly different in clo−/− retinas as compared to wild-type (p<<0.001). LE, lens. Scale bar in A (applies to all images) = 50 μm.