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Levels of pSTAT3 and total STAT3 were determined using Luminex beads in protein extracts of PBMC isolated from whole blood of tumor-bearing mice after 3 weeks of treatment with vehicle, C188-9, or PL. Level of pSTAT3 were normalized to total STAT3. The mean ± SD is shown; an asterisk (*) indicates a reduction in pSTAT3 level compared to vehicle (p=0.039).
