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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Dev Dyn. 2015 Sep 2;244(11):1404–1414. doi: 10.1002/dvdy.24321

Figure 5. Exogenous BMP2 does not alter total prostatic bud number but causes excessive branching in prostatic buds undergoing branching morphogenesis.

Figure 5

14 dpc male mouse UGS explants were grown for 7 days in media containing androgen (10nM, dihydrotestosterone, DHT) and increasing concentrations of exogenous recombinant human BMP2 (1–1000ng/ml). (A) Explants were stained as described in Fig. 2 to visualize prostatic buds. (B) Total prostatic bud number, (C) total prostatic buds undergoing branching morphogenesis and (D) number of terminal tips at the end of each branching prostatic bud were quantified. Results are mean ± SEM. Asterisk indicates significant differences from control p ≤ 0.05, n=5 per group; arrowheads and insets indicate representative buds undergoing branching morphogenesis.