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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Dev Dyn. 2015 Sep 2;244(11):1404–1414. doi: 10.1002/dvdy.24321

Figure 8. Proposed role of histone deacetylation in regulating BMP expression to shape prostate budding and branching morphogenesis.

Figure 8

Over the course of prostate development HDAC expression decreases, relieving BMP repression leading to appropriate BMP expression to control prostate budding and branching morphogenesis. Inhibition of HDACs with TSA leads to inappropriate increase in Bmp acetylation and expression leading to decreased prostatic bud formation and a greater number of tips per branch in branching buds.