Table 2.

Summary of the Sp family members’ activities and interactions.

	Sp1	Sp2	Sp3	Sp4
IE62 interaction	+ IE62 (238–258)	+ IE62 (1–226)	+ IE62 (238–258)	+ IE62 (238–258)
DNA replication	ns	ns	−−	ns
ORF28/29 promoter	ns	ns	−−	ns
ORF3 promoter	ns	ns	+++	+
gI promoter	ns	−−	+++	+
TA-Luc	ns	−−	ns	−
Sp1-TA-Luc	ns	−−	++	ns
gI promoter binding	+	−	+	−

(+) means increasing or interacting, (−) means inhibiting, (ns) means non significant influence.