Table 2.
Demographics and Clinical Characteristics of Adult Cystic Fibrosis Lung Transplant Recipients in the Low-risk (LAS <50) and High-risk (LAS ≥50) Groups
| LAS<50 (N=1119) | LAS≥50 (N=318) | p-value | |
|---|---|---|---|
| Age (years) | 31.1 ± 9.4 | 30.6 ± 9.6 | 0.44 |
| Gender (% female) | 45.1 | 54.4 | 0.003 |
| BMI (kg/m2) | 19.8 ± 5.7 | 19.1 ± 2.8 | 0.02 |
| FEV1 (% predicted) | 25.7 ± 13.9 | 23.5 ± 13.7 | 0.01 |
| FVC (% predicted) | 40.4 ± 13.0 | 35.0 ± 13.5 | <0.001 |
| Six-minute walk (%<150 feet)a | 8.5 | 26.7 | 0.003 |
| Creatinine (mg/dL) | 0.76 ± 0.45 | 0.70 ± 0.27 | 0.05 |
| Diabetic (%) | 45.3 | 50.5 | 0.10 |
| PA systolic pressure (mm Hg) | 37.8 ± 9.9 | 43.8 ± 13.2 | <0.001 |
| PA mean pressure (mm Hg) | 25.5 ± 7.1 | 30.0 ± 9.2 | <0.001 |
| PCWP (% >20) | 3.7 | 7.7 | 0.01 |
| Oxygen at rest (liters/min) | 3.0 ± 2.1 | 6.2 ± 4.4 | <0.001 |
| pCO2 (mm Hg) | 49.6 ± 13.0 | 64.7 ± 22.3 | <0.001 |
| Ventilator (% yes) | 1.6 | 36.2 | <0.001 |
| Ischemic time (hours) | 5.7 ± 1.6 | 5.8 ± 1.6 | 0.39 |
| Waiting time (days) | 115 (35, 330)† | 59 (13, 226)† | <0.001† |
| Donor/recipient CMV mismatch (%) | 63.8 | 64.5 | 0.83 |
| Non-private insurance (%) | 40.8 | 39.9 | 0.79 |
| Graduate from Secondary Education (%) | 64.0 | 61.7 | 0.47 |
| Center volume (% ≥20 tx/year) | 93.0 | 96.5 | 0.15 |
| LAS | 39.5 ± 4.3 | 71.2 ± 15.4 | <0.001 |
a
16.8% of cohort with recorded 6-MWT data (212: LAS<50, 30 LAS≥50)
†
median (IQR): Wilcoxon rank sum
LAS, Lung Allocation Score; BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; PA, pulmonary artery; PCWP, pulmonary capillary wedge pressure; pCO2, serum partial pressure of carbon dioxide; tx, transplants