Table 2.

Differential edge testing on whole‐brain networks

		“The edge connecting nodes 1 and 2 is stronger in group X than in group Y…”
	P	Node 1	Node 2
Controls	1e−6	Right precentral gyrus	Right inferior temporal gyrus
	0.00003	Right inferior frontal gyrus, pars opercularis	Right middle temporal gyrus
	0.00009	Right inferior frontal gyrus, pars opercularis	Left middle temporal gyrus
	0.00014	Right middle temporal gyrus, posterior division	Left paracingulate gyrus
	0.00015	Right middle temporal gyrus, posterior division	Left cingulate gyrus, anterior division
	0.00031	Right middle frontal gyrus	Left temporal occipital fusiform cortex
	0.00047	Right amygdala	Left frontal orbital cortex
	0.00059	Right middle frontal gyrus	Right middle temporal gyrus
	0.00059	Left frontal orbital cortex	Left temporal fusiform cortex, posterior division
	0.00105	Left cingulate gyrus, posterior division	Left cuneal cortex
	0.00108	Right superior frontal gyrus	Right lateral occipital cortex, superior division
	0.00118	Left frontal orbital cortex	Right parahippocampal gyrus, anterior division
	0.00119	Right frontal orbital cortex	Right parahippocampal gyrus, anterior division
	0.00122	Left precentral gyrus	Right temporal occipital fusiform cortex
	0.00123	Left inferior frontal gyrus, pars opercularis	Left inferior temporal gyrus
	0.00172	Right middle temporal gyrus	Right supramarginal gyrus, anterior division
	0.00193	Left lateral occipital cortex, superior division	Right temporal occipital fusiform cortex
	0.00227	Right precentral gyrus	Right temporal occipital fusiform cortex
	0.00227	Right caudate	Left cerebellum
	0.00227	Left amygdala	Left frontal orbital cortex
	0.00227	Left precentral gyrus	Left lingual gyrus
	0.00230	Left superior frontal gyrus	Left middle temporal gyrus
	0.00236	Left superior parietal lobule	Left temporal occipital fusiform cortex
	0.00241	Left inferior frontal gyrus, pars opercularis	Left temporal occipital fusiform cortex
	0.00245	Right inferior temporal gyrus, posterior division	Left frontal orbital cortex
	0.00253	Left precentral gyrus	Right inferior temporal gyrus
NF1	0.00001	Right middle temporal gyrus, posterior division	Right lateral occipital cortex, inferior division
	0.00022	Right middle temporal gyrus, posterior division	Left parahippocampal gyrus, anterior division
	0.00072	Left supracalcarine cortex	Right occipital pole
	0.00152	Left supracalcarine cortex	Left occipital pole
	0.00162	Left accumbens	Right subcallosal cortex
	0.00162	Left middle temporal gyrus	Right cuneal cortex
	0.00162	Left superior temporal gyrus, posterior division	Left precuneous cortex
	0.00163	Right middle temporal gyrus	Right lingual gyrus
	0.00164	Right middle frontal gyrus	Left inferior frontal gyrus, pars triangularis
	0.00287	Right middle temporal gyrus	Right cuneal cortex

Results indicate that 26 edges are stronger in controls than NF1 participants, and 10 edges are stronger in NF1 participants than controls. Only significant results are shown (corrected for multiple comparisons with false discovery rate at 10% using Benjamini–Hochberg). Bold text indicates one edge, significantly stronger in controls than NF1, that correlates positively with IQ in both groups.