Table 3.

Differential Modularity Clustering Results Reveal That Healthy Controls Cluster Visual and Default Mode Networks More Often Than NF1 Participants

		“Nodes 1 and 2 cluster into the same functional module more often in group X than in group Y”
	P	Node 1	Network	Node 2	Network
Control	1.24E‐05	Left lateral occipital cortex, inferior division	Visual	Left intracalcarine cortex	Visual
	3.15E‐05	Left lateral occipital cortex, inferior division	Visual	Right intracalcarine cortex	Visual
	3.47E‐05	Left lateral occipital cortex, inferior division	Visual	Left supracalcarine cortex	Visual
	3.99E‐05	Left intracalcarine cortex	Visual	Left occipital pole	Visual
	4.19E‐05	Left temporal pole	Default	Right middle temporal gyrus, posterior division	Default
	4.79E‐05	Left intracalcarine cortex	Visual	Left occipital fusiform cortex	Visual
	6.88E‐05	Right intracalcarine cortex	Visual	Left occipital fusiform cortex	Visual
	7.43E‐05	Left lateral occipital cortex, inferior division	Visual	Right cuneal cortex	Visual
	7.48E‐05	Left lateral occipital cortex, inferior division	Visual	Right supracalcarine cortex	Visual
	8.13E‐05	Left supracalcarine cortex	Visual	Left occipital pole	Visual
	8.14E‐05	Brainstem	Limbic	Right amygdala	Limbic
	8.41E‐05	Left lateral occipital cortex, inferior division	Visual	Left cuneal cortex	Visual
	0.00011	Brainstem	Limbic	Left amygdala	Limbic
	0.00011	Right intracalcarine cortex	Visual	Left occipital pole	Visual
	0.00016	Left occipital fusiform cortex	Visual	Left supracalcarine cortex	Visual
	0.00018	Right temporal pole	Default	Right superior temporal gyrus, anterior division	Default
	0.00019	Right supracalcarine cortex	Visual	Left occipital pole	Visual
	0.00021	Right cuneal cortex	Visual	Left occipital pole	Visual
	0.00024	Left cuneal cortex	Visual	Left occipital pole	Visual
NF1	0.00011	Right frontal orbital cortex	Frontoparietal	Right parahippocampal gyrus, anterior division	Default
	0.00037	Right amygdala	Limbic	Right frontal orbital cortex	Frontoparietal
	0.00077	Left intracalcarine cortex	Visual	Right cingulate gyrus, posterior division	Default
	0.00084	Right lateral occipital cortex, superior division	Default	Right supplementary motor cortex	Somatomotor
	0.00090	Right cingulate gyrus, posterior division	Default	Left supracalcarine cortex	Visual
	0.00095	Right hippocampus	Limbic	Right frontal orbital cortex	Frontoparietal

By contrast, NF1 participants show more sporadic clustering of nodes from diverse networks and a bias toward clusters in the right hemisphere. Only significant results are shown (adjusted for false discovery rate at 10% using Benjamini–Hochberg procedure). Bold text indicates modular clustering that varies inversely with Total Internalizing Symptoms in NF1 participants; i.e., as internalizing symptoms become more severe, these nodes cluster less often.