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. Author manuscript; available in PMC: 2016 Jan 16.

Published in final edited form as: Histopathology. 2015 Jun 4;68(2):183–190. doi: 10.1111/his.12725

A, B, This biopsy sample of the surface of an adenoma-like CRC was diagnosed as an adenoma, given its villous architecture, low-grade nuclei, and lack of desmoplasia or necrosis. While there are no unequivocal features of malignancy, the gland in the lower left gland shows architectural distortion that could be interpreted as indicative of malignancy, and the tissue surrounding it (inset, B) resembles lamina propria but shows a mild degree of fibroblastic hyperplasia. C, On resection, the carcinoma was almost entirely adenoma-like, and no adjacent adenoma was present.

A, B, This biopsy sample of the surface of an adenoma-like CRC was diagnosed as an adenoma, given its villous architecture, low-grade nuclei, and lack of desmoplasia or necrosis. While there are no unequivocal features of malignancy, the gland in the lower left gland shows architectural distortion that could be interpreted as indicative of malignancy, and the tissue surrounding it (inset, B) resembles lamina propria but shows a mild degree of fibroblastic hyperplasia. C, On resection, the carcinoma was almost entirely adenoma-like, and no adjacent adenoma was present.