| Molecular features of adenoma-like adenocarcinoma |
|
KRAS mutation |
14/24 (58%) |
| G12V – 5 tumors |
|
| G12D – 4 tumors |
|
| G13D – 2 tumors |
|
| G12C – 1 tumor |
|
| G12S – 1 tumor |
|
| K117N – 1 tumor |
|
|
PIK3CA mutation in addition to KRAS mutation |
4/24 (17%) |
| H1047R – 2 tumors |
|
| E545K – 2 tumors |
|
|
BRAF V600E mutation |
3/24 (13%) |
|
NRAS, AKT, PTEN, or SMAD4 mutations |
0/24 (0%) |
|
GNAS codon 201 mutation |
0/26 (0%) |
| High microsatellite instability |
4/17 (24%) |
| Additional BRAF V600E mutation, included above – 1 tumor |
| Additional KRAS G13D mutation, included above – 1 tumor |
| MLH1 promoter methylation – 1 tumor |
| No additional molecular findings – 1 tumor |
