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. 2015 Oct 22;17:295. doi: 10.1186/s13075-015-0814-z

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© Hawwa et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Comparison of the effects of weekly methotrexate (MTX) dose, route of administration and patient age on the highest to lowest methotrexate polyglutamate (MTXPG) ratio recorded in children receiving long-term MTX therapy. Dashed reference line represents a ratio >2.0-fold, which is indicative of wide fluctuations in MTXPG concentration