Table 4.

Factors associated with distant recurrence

Factor	Univariate P	Multivariate P	Multivariate HR (95% CI)
Age (>60 vs ≤60 years)	0.65	–	–
Sex (male vs female)	0.07	–	–
Location (pelvis vs other)	0.09	–	–
Size
10–20 cm vs <10 cm	0.18	0.01	1.8 (1.1–2.8)
≥20 cm vs <10 cm	0.04	0.51	1.2 (0.7–2.0)
Radiation-associated (yes vs no)	0.09	0.63	1.3 (0.5–3.8)
Histology*
Dedifferentiated, round cell & pleomorphic LPS, sarcoma NOS	<0.001	<0.001	4.7 (2.4–9.0)
Low-grade leiomyosarcoma	0.04	0.01	5.3 (1.5–19)
High-grade leiomyosarcoma	<0.001	<0.001	11.6 (5.7–23)
Solitary fibrous tumor	<0.001	<0.001	6.3 (2.6–15)
Malignant peripheral nerve sheath tumor	0.13	0.21	2.4 (0.6–9.2)
Translocation-associated sarcoma	<0.001	<0.001	6.5 (2.7–16)
Number of organs resected
1 or 2 vs 0	0.2	0.10	1.4 (0.9–2.0)
≥3	0.004	0.002	2.4 (1.4–4.4)
Vascular resection (yes vs no)	<0.001	0.43	1.2 (0.8–2.0)
Completeness of resection (R2 vs R0/R1)	0.65	–	–

^*compared to well-differentiated and myxoid liposarcoma

CI, confidence interval; LPS, liposarcoma; NOS, not otherwise specified