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. 2015 Oct 23;8:118. doi: 10.1186/s13045-015-0208-3

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© Han et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Overall schema of the study design. Individual dose titration was performed for the next cycle based on the observations from the previous cycle (solid straight arrows). Cohort dose estimation was performed to determine initial doses (broken line arrows): (i) for cohort 2, using all data obtained from cohort 1 until the initiation of cohort 2; (ii) for cohorts 3–5, using only Cycle 1 data of previous subjects. The dose of Cycle 4 was maintained until the completion of decitabine treatment (Cycle 12) (dotted lines)