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. 2015 Oct 21;11(10):e1005585. doi: 10.1371/journal.pgen.1005585

Table 1. Posterior lineage-dependent genes are targets of TCF.

Gene Homologs TCF regulation class TCF sites TCF w/Helper sites Regulatory Region (Kb)
ceh-13 * HOX1/labial Moderately Activated in ABp 10 0 8.2^
ceh-27 * NKX/scarecrow Moderately Repressed in ABp 1 1 3.4
ceh-36 * OTX/orthodenticle Strongly Activated in Aba; Strongly Repressed in ABp 6 0 5.1
ceh-43 * DLX/distalless Indirect 0 0 2.4
ceh-6 * POU3F4 Strongly Activated in Aba; Weakly Activated in ABp 6 2 6.8^
cwn-1 WNT Moderately Activated 2 0 1.9
cwn-2 WNT Weakly Activated in ABa and E; Weakly Repressed in ABp 7 1 6.1
elt-6 # GATA4/5/6 Moderately Activated 2 0 2.4
end-1 GATA1 Activated + Repressed 2 2 2.5
end-3 GATA1 Activated + Repressed 3 1 2.2
ets-7 ELK Moderately Activated 2 0 1.5^
mom-2 WNT Unregulated 1 0 3.1
mir-57 microRNA Weakly Activated 1 1 2.3
nhr-25 * NR5A Weakly Activated in Aba; Moderately Activated in ABp 6 2 8.9^
nhr-67 * NR2E/tailless Weakly Activated in ABa; Moderately Activated in MS 7 1 5.1
nob-1 * HOX9-13/Abd-B Strongly Activated in ABp and C 5 3 5.4
pal-1 * CDX/caudal Moderately Activated in AB Weakly Activated in D; Activated + Repressed in C 6 1 4.6^
pax-3 * PAX3/paired Moderately Activated 2 1 2.6
sem-2 * SOX11 Strongly Repressed in AB 6 0 3.9
tbx-11 TBX2 subfamily Moderately Repressed except in ABp 3 0 2.1
tlp-1 # ZNF503/703 Strongly Repressed in AB 4 2 5.1
unc-130 * FOXD Weakly Activated 11 2 10.5^
unc-30 PITX Strongly Repressed 6 3 6.2^
vab-7 * EVX/even-skipped Moderately Activated 1 1 3.6

* deletion lethal,

known embryonic target [40,64,67],

# known post-embryonic target [85,86],

^ fosmid protein fusion reporter, so additional elements may lie outside the 5’ regulatory region.