Table 1. Posterior lineage-dependent genes are targets of TCF.
Gene | Homologs | TCF regulation class | TCF sites | TCF w/Helper sites | Regulatory Region (Kb) |
---|---|---|---|---|---|
ceh-13 * † | HOX1/labial | Moderately Activated in ABp | 10 | 0 | 8.2^ |
ceh-27 * | NKX/scarecrow | Moderately Repressed in ABp | 1 | 1 | 3.4 |
ceh-36 * | OTX/orthodenticle | Strongly Activated in Aba; Strongly Repressed in ABp | 6 | 0 | 5.1 |
ceh-43 * | DLX/distalless | Indirect | 0 | 0 | 2.4 |
ceh-6 * | POU3F4 | Strongly Activated in Aba; Weakly Activated in ABp | 6 | 2 | 6.8^ |
cwn-1 | WNT | Moderately Activated | 2 | 0 | 1.9 |
cwn-2 | WNT | Weakly Activated in ABa and E; Weakly Repressed in ABp | 7 | 1 | 6.1 |
elt-6 # | GATA4/5/6 | Moderately Activated | 2 | 0 | 2.4 |
end-1 † | GATA1 | Activated + Repressed | 2 | 2 | 2.5 |
end-3 † | GATA1 | Activated + Repressed | 3 | 1 | 2.2 |
ets-7 | ELK | Moderately Activated | 2 | 0 | 1.5^ |
mom-2 | WNT | Unregulated | 1 | 0 | 3.1 |
mir-57 | microRNA | Weakly Activated | 1 | 1 | 2.3 |
nhr-25 * | NR5A | Weakly Activated in Aba; Moderately Activated in ABp | 6 | 2 | 8.9^ |
nhr-67 * | NR2E/tailless | Weakly Activated in ABa; Moderately Activated in MS | 7 | 1 | 5.1 |
nob-1 * | HOX9-13/Abd-B | Strongly Activated in ABp and C | 5 | 3 | 5.4 |
pal-1 * | CDX/caudal | Moderately Activated in AB Weakly Activated in D; Activated + Repressed in C | 6 | 1 | 4.6^ |
pax-3 * | PAX3/paired | Moderately Activated | 2 | 1 | 2.6 |
sem-2 * | SOX11 | Strongly Repressed in AB | 6 | 0 | 3.9 |
tbx-11 | TBX2 subfamily | Moderately Repressed except in ABp | 3 | 0 | 2.1 |
tlp-1 # | ZNF503/703 | Strongly Repressed in AB | 4 | 2 | 5.1 |
unc-130 * | FOXD | Weakly Activated | 11 | 2 | 10.5^ |
unc-30 | PITX | Strongly Repressed | 6 | 3 | 6.2^ |
vab-7 * | EVX/even-skipped | Moderately Activated | 1 | 1 | 3.6 |