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. 2015 Oct 24;16:857. doi: 10.1186/s12864-015-2067-2

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© Black et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Heterogeneous positions identified across the whole population genomes relative to M. tuberculosis H37Rv reference genome. aThe rifampicin mono-resistant isolate (R721) for patient 1 shows numerous heterogeneous variants relative to M. tuberculosis H37Rv while the follow-up MDR isolate (R807) has none. (b) For patient 2 the rifampicin mono-resist isolate (R912) showed no heterogeneous variants relative to M. tuberculosis H37Rv, while the follow-up MDR isolate (R1210) had numerous heterogeneous variants. R912 shared 2 variants (Rv0667 and Rv0672) with R1210, where the variant was present at 100 % in R912 but was a heterogeneous variant in R1210