Fig. 6.

a In vivo imaging of representative control, DRA-challenged and DRA-challenged and budesonide-treated mice injected with MMPSense680 after 11 weeks from the beginning of DRA administration (3 weeks after ending of DRA administration). b Score of collagen deposition measured by Masson’s Trichrome staining at different time points after beginning of DRA, in the absence or presence of budesonide treatment beginning after 4 weeks of DRA. Values are expressed as mean ± SEM of three different experiments. The dashed line represents the average value of control animals treated with saline. c Fluorescence signal quantification measured by FMT in MMPSense680-injected mice at different time points after beginning of DRA, in the absence or presence of budesonide treatment beginning after 4 weeks of DRA. Eight mice were used for every time points and the experiment was replicated three times. Values are expressed as mean ± SEM of the three different experiments. The dashed line represents the average value of control animals treated with saline. Statistical differences were tested by one-way ANOVA followed by Dunnett’s t post hoc test for group comparisons. P < 0.05 and **P < 0.01