Table 1.

Differences between BMSCs and ASCs in co-culture with ECs

	BMSCs	ASCs
3D matrix used for co-culture	Fibrin [9, 38, 39, 42, 43, 49], polyurethane [37], type I collagen [38], fibrin + type I collagen in different ratios [38]	Fibrin [9, 33, 43, 51, 52]
Pericytic marker	α-SMA [9, 37, 46], NG2 [37], CD146 [37]	α-SMA [9, 50], NG2 [33]
Paracrine factors	HGF, TIMP1, TIMP2 [9]	HGF, TNF-α [51], PD-ECGF, FGF-2, MMP-9, Ang-2, pentraxin-3 [33], ECM proteins: collagen IV, fibronectin [50]
Altered gene expression	FGF-2 ↑, TGFB1 ↑, VEGFA ↑ [42], vWF ↑, CD31 ↑, VE-cadherin ↑, angiopoietin-related protein 4 ↑, CD34 ↑, CD93 ↑, CDH5 ↑ [45], MMPs ↑ [39]	CD31 ↑, VE-cadherin ↑, VEGFR-2 ↑, vWF ↑ [33]
Endothelial cell type	HUVECs [9, 37–39, 43, 45, 46, 48, 49],EPCs [37], ECFCs [42]	HUVECs [9, 33, 43, 51], OECs [33, 52]
MMPs important for network formation and ECM degradation	Yes (in contrast to fibroblasts) [39, 49]	Yes [52], to a lesser extent as plasmin family proteases [51]

BMSCs and ASCs have different effects on ECs and show altered behavior concerning pericytic marker expression, paracrine factors, gene expression, and importance of MMPs for network formation. Furthermore, different matrices as well as different EC types were used to investigate effects of MSCs on ECs