Table 2.
Correlation analysis between erythrocyte membrane phospholipid fatty acids and cardiovascular risk factors
| BMI | Waist circumference | TG | Apo B | TC | LDL-C | HDL-C | SBP | DBP | FBS | Insulin | AI | HbA1c | HOMA-IR | homocysteine | hs-CRP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C14:0 Myristic acid | 0.283* | 0.285* | 0.480** | 0.130 | −0.053 | −0.100 | −0.322* | 0.150 | 0.177 | 0.308* | 0.429** | 0.343** | 0.173 | 0.457** | 0.145 | 0.088 |
| C16:0 Palmitic acid | 0.256 | 0.279* | 0.375** | −0.007 | −0.198 | −0.299* | −0.297* | 0.480** | 0.496** | 0.146 | 0.129 | 0.122 | 0.000 | 0.209 | 0.033 | 0.139 |
| C18:0 Stearic acid | 0.043 | 0.059 | −0.341** | −0.189 | −0.058 | 0.032 | 0.100 | −0.326* | −0.329* | −0.150 | −0.011 | −0.205 | −0.004 | −0.064 | −0.122 | −0.038 |
| C24:0 Lignoceric acid | −0.041 | 0.134 | −0.058 | −0.075 | −0.015 | 0.061 | 0.044 | −0.176 | −0.221 | 0.163 | −0.085 | −0.053 | 0.043 | −0.037 | 0.138 | −0.311* |
| C16:1n7, Palmitoleic acid | 0.059 | −0.022 | 0.454** | 0.114 | 0.091 | −0.079 | 0.023 | 0.140 | 0.209 | 0.228 | 0.098 | 0.078 | −0.008 | 0.123 | 0.088 | 0.122 |
| C18:1n9, Oleic acid | 0.099 | 0.213 | 0.523** | 0.345** | 0.021 | −0.068 | −0.157 | .0387** | 0.407** | 0.033 | 0.269* | 0.212 | 0.034 | 0.274* | 0.269* | 0.110 |
| C20:1n9, Eicosenoic acid | 0.093 | 0.043 | −0.328* | −0.107 | −0.156 | 0.022 | −0.127 | −0.288* | −0.249 | 0.072 | 0.054 | 0.012 | 0.171 | 0.076 | −0.184 | 0.115 |
| C24:1n9, Nervonic acid | −0.057 | 0.003 | −0.227 | −0.077 | 0.048 | 0.160 | 0.106 | −0.316* | −0.338* | 0.098 | −0.056 | −0.020 | 0.105 | −0.039 | 0.115 | −0.201 |
| C18:2n6 (LA) | −0.214 | −0.335* | −0.179 | 0.066 | 0.364** | 0.376** | 0.216 | −0.052 | −0.069 | −0.245 | −0.109 | 0.013 | −0.123 | −0.195 | −0.145 | 0.037 |
| C18:3n6 (GLA) | 0.125 | 0.090 | 0.359** | 0.085 | 0.049 | 0.033 | −0.219 | 0.018 | 0.044 | 0.324* | 0.349** | 0.265* | 0.250 | 0.286* | 0.029 | 0.041 |
| C20:2n6 (EDA) | −0.136 | −0.140 | −0.092 | 0.051 | 0.104 | 0.005 | 0.283* | −0.096 | −0.087 | −0.113 | −0.056 | −0.248 | 0.055 | −0.038 | 0.079 | −0.042 |
| C20:3n6 (DGLA) | 0.168 | 0.080 | 0.065 | 0.127 | 0.095 | 0.149 | −0.160 | 0.212 | 0.241 | 0.046 | 0.163 | 0.181 | 0.209 | 0.137 | 0.127 | 0.245 |
| C20:4n6 (AA) | −0.080 | −0.020 | −0.469** | −0.284* | −0.159 | 0.012 | 0.004 | −0.284* | −0.276* | −0.034 | −0.188 | −0.201 | 0.108 | −0.220 | −0.051 | 0.005 |
| C22:4n6 (DTA) | 0.165 | 0.147 | −0.244 | −0.147 | −0.084 | 0.065 | −0.140 | −0.027 | −0.011 | 0.145 | 0.165 | −0.037 | 0.131 | 0.130 | 0.003 | 0.064 |
| C22:5n6 (DPA) | −0.178 | −0.104 | 0.128 | 0.199 | 0.287* | 0.245 | 0.166 | −0.032 | −0.090 | −0.174 | −0.165 | −0.001 | −0.265* | −0.224 | 0.048 | −0.006 |
| C18:3n3 (ALNA) | 0.024 | −0.057 | 0.215 | 0.011 | −0.029 | −0.081 | −0.048 | 0.085 | 0.050 | 0.043 | 0.087 | 0.060 | −0.168 | −0.012 | −0.162 | 0.123 |
| C20:5n3 (EPA) | 0.181 | 0.202 | −0.166 | −0.113 | −0.221 | −0.237 | −0.041 | 0.017 | 0.032 | 0.138 | −0.035 | −0.053 | 0.063 | 0.055 | 0.063 | −0.150 |
| C22:5n3 (DPA) | 0.182 | 0.229 | −0.185 | −0.224 | −0.316* | −0.247 | −0.151 | −0.091 | −0.090 | 0.185 | −0.005 | −0.096 | 0.048 | 0.072 | −0.093 | −0.108 |
| C22:6n3 (DHA) | 0.874 | 0.075 | 0.039 | −0.117 | −0.143 | −0.227 | −0.107 | 0.044 | 0.036 | 0.114 | −0.147 | 0.008 | 0.011 | −0.082 | –.0810 | –.0582 |
| D5D | −0.233 | −0.126 | −0.035** | −0.291* | −0.179 | −0.117 | 0.158 | −0.366** | −0.400** | −0.056 | −0.248 | −0.302* | −0.155 | −0.240 | −0.179 | −0.228 |
| D6D | 0.191 | 0.191 | 0.365** | 0.048 | −0.070 | −0.078 | −0.284* | 0.003 | 0.049 | 0.383** | 0.364** | 0.089 | 0.303* | 0.330* | 0.087 | 0.044 |
| D9D | 0.042 | 0.119 | 0.546** | 0.318* | 0.016 | −0.097 | −0.167 | 0.453** | 0.459** | 0.060 | 0.179 | 0.226 | −0.020 | 0.196 | 0.236 | 0.127 |
Mean ± S.D.; Significantly correlated by pearson correlation analysis at *p <0.05, and **p <0.01 and respectively
AA Arachidonic acid, ALNA α-Linolenic acid, DGLA Dihomo-γ-linolenic acid, DHA Docosahexanoic acid, DPA Docosapentaenoic acid, DTA Docosatetraenoic acid, D5D delta-5-Desatuase (C20:4 ω-6/C20:3 ω-6), D6D delta-6-Desatuase(C18:3 ω-6/C18:2 ω-6), D9D delta-9-Desatuase(C18:1 ω-9/C18:0), EDA Eicosadienoic acid, EPA Eicosapentaenoic acid, GLA γ-linolenic acid, LA Linoleic acid, MUFA monosaturated fatty acid, PUFA polysaturated fatty acid, SFA saturated fatty acid, C22:5 ω-6(Docosapentaenoic acid, DPA) = osbond acid; C22:5 ω-3 (Docosapentaenoic acid, DPA) = clupanodonic acid, BMI body mass index, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, TG Triglyceride, TC total cholesterol, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein, cholesterol, AI (TC-HDL)/HDL, Apo B apolipoprotein B, FBS fasting blood sugar, HOMA-IR homeostasis model assessment of insulin resistance, hs-CRP high sensitivity C-reactive protein