Table 1.
CeO2 nanoparticles attenuate peritonitis induced increase in biomarkers of AKI
| Analyte | Sham control 3 h | CeO2 3 h | Peritonitis 3 h | Peritonitis + CeO2 3 h | Sham control 18 h | CeO2 18 h | Peritonitis 18 h | Peritonitis + CeO2 18 h |
|---|---|---|---|---|---|---|---|---|
| β2-Microglobulin (µg/mL) | 54.00 ± 3.00 | 49.67 ± 2.40 | 76.00 ± 1.53*$ | 77.33 ± 1.76*$ | 52.00 ± 3.51 | 32.67 ± 1.45* | 128.00 ± 5.85*$ | 78.33 ± 7.21*$# |
| Cystatin-C (ng/mL) | 578.67 ± 14.25 | 633.00 ± 30.57 | 686.00 ± 14.47 | 690.33 ± 42.10 | 699.67 ± 52.67 | 555.33 ± 41.63 | 1890.00 ± 62.45*$ | 1093.33 ± 37.56*$# |
| KIM-1 (ng/mL) | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | 3.27 ± 0.13 | 2.50 ± 0.10# |
| Osteopontin (ng/mL) | 10.80 ± 1.20 | 11.00 ± 0.58 | 11.00 ± 0.58 | 12.33 ± 0.33 | 9.70 ± 0.00 | 7.93 ± 0.23* | 72.33 ± 4.84*$ | 36.33 ± 1.76*$# |
| VEGF-A (pg/mL) | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | Below LLOQ | 459.00 ± 12.70 | 296.67 ± 31.33# |
LLOQ lower limit of quantitation
*P < 0.05 compared to control group, $ P < 0.05 compared to CeO2 group and # P < 0.05 compared to peritonitis group (n = 6/group)