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. 2015 Oct 24;11:65. doi: 10.1186/s12990-015-0068-4

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© Ferrari et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Piezo2 in sensory neurons innervating the skin do not play a role in endothelin-1-induced stimulus-dependent hyperalgesia. Rats were treated for 3 consecutive days with intrathecal injection of the combination of 3 sequences of ODN antisense (AS, dark symbols) or mismatch (MM, open symbols) against Piezo2 mRNA. On the 4th day, endothelin-1 (100 ng) was injected on the dorsum of the hind paw. Four mechanical stimuli, 5 min apart from each other, were performed, starting 15 min after endothelin-1 injection. No difference was observed between the groups in the decrease in the nociceptive threshold subsequent to the mechanical stimuli, indicating that Piezo2 channels in the DRG neurons are not involved in stimulus-dependent hyperalgesia induced by endothelin-1. (p = 0.9895, non-significant, when the groups are compared, two-way repeated measures ANOVA followed by Bonferroni’s post hoc test; N = 6 paws per group)