Table 1.
Characteristics | First series of resected primary GIST | Second series of metastatic or locally advanced at diagnosis GIST |
---|---|---|
N | 87 | 22 |
Male | 42 | 13 |
Female | 45 | 9 |
Age (years) | 65 (22–84) | 64 (39–79) |
Median size (mm) | 58 (17–400) | 90 (45–240) |
Location | ||
Stomach | 52 (60 %) | 8 (36 %) |
Small bowel | 24 (28 %) | 11 (50 %) |
Other locations | 11 (12 %) | 3 (14 %) |
Mitotic index per 50 HPF | ||
≤ 5 | 51 (59 %)a | 5 (26 %)a |
6–10 | 12 (14 %)a | 4 (21 %)a |
> 10 | 23 (27 %)a | 10 (52 %)a |
Unknown | 1 | 3 |
Mutation status | ||
KIT ex 11 | 40 (54 %)a | 12 (75 %)a |
KIT ex 9 | 5 (7 %)a | 3 (19 %)a |
KIT ex 13 | 1 (1 %)a | 1 (6 %)a |
KIT ex 17 | 2 (3 %)a | 0 |
PDGFRA ex 18 | 11 (15 %)a | 0 |
D842V | 9 | 0 |
No mutation on KIT or PDGFRA hotspots | 15 (20 %)a | 0 |
Unknown | 13 | 6 |
Prevalence of the variant KITL541 | 15 (17 %) | 9 (41 %) |
aPercentages are determined on the evaluable cases
HPF high-power field