Table 2.
Number of ACEI starters in different categories both according to the prescription data and medical records
| Total (N = 1132) | Switchers to ARB (N = 180) (16 %) | Switchers to other antihypertensive than ARB (N = 106) (9.5 %) | Stoppers (N = 261) (23 %) | Continuation (N = 585) (51.5 %) | ||
|---|---|---|---|---|---|---|
| Out of study (N = 167) (14.5 %) | Death (N = 119) (10.5 %) | End of study (N = 299) (26.5 %) | ||||
| Definite ADR (N = 222) (19.5 %) | ||||||
| Cough (N = 163) | 83 | 25 | 35 | 4 | 3 | 13 |
| Angioedema (N = 7) | 3 | 1 | 1 | 0 | 1 | 1 |
| Othersa (N = 52) | 15 | 16 | 15 | 3 | 1 | 2 |
| Total | 101 (56 %) | 42 (39.5 %) | 51 (19.5 %) | 7 | 5 | 16 |
| 28 (5 %) | ||||||
| Definite Non-ADR (N = 48) (4.3 %) | ||||||
| No need (N = 11) | 0 | 1 | 10 | N/A | N/A | N/A |
| Not effective (N = 15) | 4 | 4 | 7 | N/A | N/A | N/A |
| Othersb (N = 22) | 6 | 5 | 11 | N/A | N/A | N/A |
| Total | 10 (5.5 %) | 10 (9.5 %) | 28 (11 %) | N/A | ||
| Nothing mentioned (N = 628) (55.5 %) | 40 (22.5 %) | 25 (23.5 %) | 132 (50.5 %) | 124 | 89 | 218 |
| 431 (73.5 %) | ||||||
| Health problem mentioned (N = 234) (20.7 %) | ||||||
| Probable ADRc (N = 197) | 22 | 20 | 43 | 35 | 21 | 56 |
| Non-probable ADRd (N = 37) | 7 | 9 | 7 | 1 | 4 | 9 |
| Total | 29 (16 %) | 29 (27.5 %) | 50 (19 %) | 36 | 25 | 65 |
| 126 (21.5 %) | ||||||
The interval between a renewal of an ACEI prescription and the theoretical end date of the previous prescription was 6 months. ACEI Angiotensin converting enzyme inhibitor, ARB Angiotensin receptor blocker, N/A Not applicable
aAllergic reaction (N = 1), Renal dysfunction (N = 2), Runny nose (N = 2), Sexual dysfunction (N = 1), Tiredness (N = 6), Not mentioned (N = 9), Chest pain (N = 1) Decreased taste (N = 1), Dizziness (N = 9), Dizziness plus (N = 1), Gastrointestinal (N = 4), Headache (N = 2), Hiccups (N = 1), Hyperkalemia (N = 2), Itching (N = 3), Itching rash (N = 5), Muscular crumps (N = 1), Nausea (N = 1)
bAngioedema history (N = 1), Bad taste (N = 1), Cerebrovascular event (N = 1), Do not like (N = 1), Drug interaction (N = 2), Disease interaction (N = 3), Hypotension (N = 2), Self-stop (N = 3), Surgery (N = 1), Not mentioned (N = 5), Short change (N = 2)
cAllergic reaction (N = 1), Angioedema (N = 2), Cough (N = 48), Cough plus (N = 11), Asthma (N = 4), Bronchitis (N = 26), Common cold (N = 6), COPD (N = 8), Dry cough (N = 7), Flu (N = 1), Infectious cough (N = 28), Pneumonia (N = 7), Cough with sputum (N = 4), Dizziness (N = 16), Dizziness plus (N = 1), Dyspnea (N = 5), Hypersensitivity (N = 1), Itching (N = 2), Itching rash (N = 3), Itching throat (N = 2), Rash (N = 3), Tiredness plus (N = 1), Tiredness (N = 3), Sexual dysfunction (N = 2), Shortness breath (N = 5)
dAnxiety (N = 1), Bad feeling (N = 6), Body pain (N = 1), Edema (N = 1), Gastrointestinal (N = 5), Hair loss (N = 1), Hospitalization (N = 1), Hand hypoxia (N = 1), Increased blood urea (N = 1), Muscular crumps (N = 5), Muscular pain (N = 1), Nausea (N = 2), Not tolerate (N = 4), Renal dysfunction (N = 3), Runny nose (N = 1), Swollen feet (N = 1), Not mentioned (N = 1) Pulmonary embolism (N = 1)