Table 4.
Average miRNAs fold change values in pancreatic cancers in comparison with normal tissues
| miRNAs | Internal controls | ||||
|---|---|---|---|---|---|
| Spike | U6 | miR-16 | U91 | U6 + U91 | |
| miR-21 | 14.56 ± 6.468; p < 0.01 | 5.44 ± 2.73; p < 0.01 | 7,03 ± 3,614; p < 0.01 | 17.71 ± 11.922; p < 0.01 | 9.67 ± 6.287; p < 0.01 |
| miR-96 | −1.04 ± 0.668; p > 0.05 | −3.22 ± 1.766; p < 0.01 | −2,32 ± 1.376; p < 0.01 | −1.17 ± 0.831; p > 0.05 | −1.85 ± 1.134; p < 0.01 |
| miR-148a | 1.25 ± 0.429; p > 0.05 | −2.04 ± 0.92; p < 0.01 | −1.33 ± 0.782; p < 0.05 | 1.06 ± 0.549; p > 0.05 | −1.27 ± 0.594; p > 0.05 |
| miR-155 | 15.1 ± 8.786; p < 0.01 | 5.05 ± 2.992; p < 0.01 | 6.39 ± 3.312; p < 0.01 | 13.36 ± 9.477; p < 0.01 | 8.79 ± 5.675; p < 0.01 |
| miR-196a | 1.09 ± 0.306; p > 0.05 | −2.22 ± 1.09; p < 0.01 | −1.35 ± 0.905; p > 0.05 | 1.13 ± 0.676; p > 0.05 | −1.34 ± 0.726; p < 0.05 |
| miR-217 | −8.69 ± 4.99; p < 0.01 | −24,39 ± 13.616; p < 0.01 | −16.39 ± 9.71; p < 0.01 | −9.09 ± 5.323; p < 0.01 | −7.19 ± 4.161; p < 0.01 |
MicroRNAs expression was measured relative to four different internal controls and combination of two of them (U6 + U91). Negative fold change values indicate downregulation of the miRNAs in cancer samples. Data are presented as means ± standard deviation (SD). p < 0.05 is considered as statistically significant. P values of the Student’s t-test for the significant differences are shown in bold