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. 2015 Oct 24;22:97. doi: 10.1186/s12929-015-0201-8

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© Porto et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Identification of the main sources of ROS production and antioxidant enzyme capacity by oxidative stress pathway analysis. Bar graphs show the effect of different oxidant proteins inhibitors on ROS production and antioxidant proteins inhibitors on ROS reduction. ROS levels were analyzed by DHE and DCF fluorescence intensity. Unshaded bars represent basal ROS levels, and shaded bars show ROS levels after blockade. Abbreviations: NADPH oxidase (NADPHox), xanthine oxidase (XO), cytochrome P450 (CYP450), superoxide dismutase (SOD), catalase (CAT), gluthatione peroxidase (GPx). Values are means ± SEM, *p < 0.05 vs. matched basal