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. 2015 Oct 24;22:97. doi: 10.1186/s12929-015-0201-8

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© Porto et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Augmented ROS leads to DNA damage and apoptosis of HSCs during aging. a The top panel shows typical photographs of comets with higher DNA fragmentation in the middle and aged groups. Bar graphs show the percentage of DNA in the tail and the tail moment. b Table shows the average percentage of viable cells, early apoptosis, late apoptosis and necrosis detected by annexin-V and PI staining. c Correlation between intracellular ROS levels and apoptosis. Values are means ± SEM, *p < 0.05 vs. young. ^# p < 0.05 vs. middle