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. 2015 Oct 24;22:97. doi: 10.1186/s12929-015-0201-8

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© Porto et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Scheme showing multiple age-related factors regulating hematopoietic stem cell function. Alterations in HSC function observed in aging: generation and main types of damage induced by ROS, different mechanisms of oxidative cellular/molecular damage and the potential role of antioxidants on HSC fate during the aging process. Lines with arrowhead indicate stimulation and lines with crosshead indicate inhibition. A line with a double arrowhead indicates a normal condition. Abbreviations: hematopoietic stem cells (HSC), reactive oxygen species (ROS), NADPH oxidase (NADPHox), cytochrome P450 (CYP450), xanthine oxidase (XO), lymphoid cells (L), myeloid cells (M), tumoral necrosis factor (TNF), interleukin-12p70 (IL-12), interleukin-6 (IL-6)