Fig 11. Schematic representation of quercetin induced apoptosis through twist regulation.

Quercetin being a potent anti-oxidant it reduces the cellular stress. This indirectly reduced the activation of p38MAPK in survival pathway which prevents the stabilization of twist. Quercetin reduced twist gene expression through suppression of Cyclin D1, and induced p16 and p21 to arrest the cells at G1 phase of cell cycle, thereby induced apoptosis. Our data thereby reveal the mechanism of quercetin induced apoptosis through twist regulation.