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. 2015 Oct 22;10(10):e0141020. doi: 10.1371/journal.pone.0141020

Fig 3. Relationship between HCT116 cell cycle progression and apoptosis induced by combination of rosiglitazone and LA-12.

Fig 3

(a) Caspase-3 activation (% of all cells with active caspase-3) related to the cell cycle progression (flow cytometry) in HCT116 wt and Bax-/- cells following their pretreatment (24 h) with rosiglitazone (RGZ, 50 μM), and subsequent treatment (48 h) with LA-12 (0.75 μM) (b) Percentage of apoptotic cells (with active caspase-3) in G1 cell cycle phase, quantification of data from a). Results are means + S.E.M. or representatives of three independent experiments. Statistical significance: P < 0.05, * versus control, ‡ versus RGZ, Ο versus LA-12, and Δ for wt versus Bax-/- cells.