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. 2015 Oct 22;10(10):e0141020. doi: 10.1371/journal.pone.0141020

Fig 4. The role of p53 and Chk2 proteins in rosiglitazone-mediated enhancement of LA-12-induced apoptosis.

Fig 4

Cleavage of caspase-9, caspase-3, PARP and the level of Chk2 and p53 proteins in HCT116 wt, Chk2-/- and p53-/- cells pretreated (24 h) with rosiglitazone (RGZ, 50 μM), and subsequently treated (48 h) with LA-12 (0.75 μM), detected by Western blotting. Results are representatives of three independent experiments.