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. 2015 Oct 22;10(10):e0140852. doi: 10.1371/journal.pone.0140852

Fig 3. Defective phenotype of mDCs for migration from periphery to lymphoid tissues.

Fig 3

(a) A representative flowcytogram of a healthy control subject showing CCR7 and CCR8 expression on mDCs. The open pink histograms shows the isotype control, solid grey histogram shows the unstimulated control and solid blue histogram shows the stimulated control. The ability of mDCs to upregulate chemokine receptors CCR7 (b) and CCR8 (c) in response to a 5-hour stimulation to LPS (500ng/ml) by flowcytometry in ART-naive patients with CD4+ T-cell counts<250 cells/μL (n = 9) and CD4+ T-cell counts>250 cells/μL (n = 5) and compared with patients on ART with CD4+ T-cell counts>350 cells/μL (n = 9). The patients in late stage of HIV had significantly lower ability to up-regulate CCR8 (p<0.05) as compared to HCs. Data are represented as mean±SD. **, P<0.01; ns not significant.