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. 2015 Oct 22;10(10):e0140852. doi: 10.1371/journal.pone.0140852

Fig 5. Cytokine secretion from mo-DCs post LPS-stimulation.

Fig 5

Level of inflammatory cytokines (IL-12, TNFα, IL-10 and IL-8) was measured in the culture supernatants of mo-DCs after LPS-stimulation (500ng/ml) for 2 days by multiplex cytometric bead array (CBA) technique in 23 ART-naive patients in advanced stage of HIV disease; 33 patients in early stage, 36 patients on ART and 24 HCs and the results were expressed in pg/ml. The HIV infected patients in advanced stage of disease (CD4+ T-cell counts<250 cells/μL) had significantly lower secretion of (a) IL-12, (b) TNFα, (c) IL-10 and (d) IL-8 as compared to HCs (p<0.05). Patients with higher CD4+ T-cell counts had higher levels of IL-12, TNFα and IL-10, although statistically non-significant. Patients on ART did not depict significant increase in the levels of these cytokines. Data are represented as mean ± SD. *, P<0.05.