Skip to main content
. 2015 Oct 22;10(10):e0140852. doi: 10.1371/journal.pone.0140852

Fig 7. Expression levels of SOCS-3, SHP-1, NF-κB1 and JAK2 in different study groups.

Fig 7

The fold change in the expression of SOCS-3, SHP-1, NF-κB and JAK2 was measured in ART-naive patients (n = 9) with CD4+ T-cell counts<250 cells/μL and patients with CD4+ T-cell counts>250 cells/μL (n = 9) along with HCs (n = 9) and patients on ART (n = 9). Kruskall-Wallis (KW) test was performed for comparisons between multiple groups with pairwise comparisons using Dunn's multiple comparison adjustment for an overall p values <0.05. (a) The expression of SOCS-3 was significantly higher in patients with CD4+ T-cell counts<250 cells/μL as compared to HCs and patients on ART (p<0.05). (b) The expression of SHP-1 mRNA levels were also significantly higher in patients in advanced HIV-disease as compared to HCs (p<0.05). (c) The expression of NF-κB1 and (d) JAK2 on the other hand was significantly lower (p<0.05) in this patient group compared to HCs. Data are represented as mean ± SD. *, P<0.05.