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. 2015 Oct 22;10(10):e0141258. doi: 10.1371/journal.pone.0141258

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© 2015 Anzai et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — Accumulation of CAV2 was observed in OHCs around apical part of cochlea and colocalized with prestin in 3-week-old control and Cx26^f/fP0Cre mice. z-stacks of images were collected at 0.5-μm intervals (B, C, E, F), and the images of OHCs were reconstructed with graphics software (A, D). Double labeling for CAV2 and prestin revealed that OHCs of Cx26^f/fP0Cre mice had an altered, hourglass-like shape and that CAV2 accumulated near the basolateral plasma membranes. In contrast, CAV2 accumulation was mainly observed surrounding the shrunken site of OHCs in Cx26^f/fP0Cre mice (arrowheads in D). OHCs, outer hair cells.