Table 3. Genotype frequencies and associated risks of silicosis in case and control subjects.
| Variables | Cases(No, %) | Controls(No, %) | Crude OR (95%CI) | Adjusted OR(95%CI) a | p value |
|---|---|---|---|---|---|
| Nalp3 | |||||
| IVS8-7652A>C | |||||
| AA | 70(39.1) | 70(34.8) | 1.00 | 1.00 | |
| AC | 80(44.7) | 93(46.3) | 0.86 (0.55–1.34) | 0.86 (0.55–1.35) | 0.9685 |
| CC | 29(16.2) | 38(18.9) | 0.77 (0.43–1.37) | 0.76 (0.42–1.36) | 0.4531 |
| Ex4-849C>T | |||||
| CC | 157(87.7) | 190(94.5) | 1.00 | 1.00 | |
| CT | 22(12.3) | 11(5.5) | 2.42 (1.14–5.14) | 2.40 (1.12–5.12) | 0.0239 |
| IL-1β | |||||
| -580C>T | |||||
| CC | 55(30.7) | 54(26.9) | 1.00 | 1.00 | |
| CT | 91(50.8) | 100(49.8) | 0.89 (0.56–1.43) | 0.87 (0.55–1.40) | 0.8133 |
| TT | 33(18.4) | 47(23.4) | 0.69 (0.39–1.23) | 0.68 (0.38–1.22) | 0.2370 |
| Ex5+14C>T | |||||
| CC | 173(96.6) | 188(93.5) | 1.00 | 1.00 | |
| CT | 6(3.4) | 13(6.5) | 0.50 (0.19–1.35) | 0.52 (0.19–1.40) | 0.1946 |
| Caspase-1 | |||||
| Ex2+37G>A | |||||
| GG | 154(86.0) | 192(95.5) | 1.00 | 1.00 | |
| GA | 25(14.0) | 9(4.5) | 3.46 (1.57–7.64) | 3.62 (1.63–8.02) | 0.0038 |
a Data were calculated using unconditional logistic regression and adjusting for age, smoking status, and CDE.
CI, confidence interval; OR, odds ratio.