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. 2015 Oct 23;10(10):e0140919. doi: 10.1371/journal.pone.0140919

Fig 5. No changes in cellular lactate production in POAG or LHON lymphoblasts.

Fig 5

Lymphoblasts were incubated in high glucose media (RPMI supplemented with glucose increased to 4mg/ml from the standard RPMI level of 2, uridine at 50 μg/ml, pyruvate at 1mM + 15% heat-inactivated FCS) for 48 hours prior to lymphoblast media supernatant being harvested for lactate measurement. There was no significant difference in extracellular lactate levels (reflective of cellular lactate production) between POAG lymphoblasts and controls, or between LHON lymphoblasts and controls. Data is median (IQR), n = 20 cont1, n = 15 POAG, n = 6 cont2 and n = 6 LHON.