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. 2015 Oct 11;2015:417586. doi: 10.1155/2015/417586

Figure 2.

Figure 2

Blocking P-selectin and PSGL-1 decrease extravasation and decrease homing of MM cells to the BM in vivo. The effect of P-selectin- and PSGL-1-blocking antibodies on the number of circulating MM cells detected as calcein-AM-positive MM cells detected by flow cytometry at 50 minutes of blood aspiration after injection (a). The effect of blocking P-selectin and PSGL-1 on MM cell homing to the BM shown as the number of calcein-AM-positive cells detected in the BM, analyzed by flow cytometry, and normalized to untreated cells (b). Results are depicted as mean ± s.d. and statistical significance was analyzed by student t-test (n = 5 mice per group). Values were considered significant for ∗ p < 0.05.