(a) The “Top Tox List” displays the response mechanisms, which are most affected by several stress factors emerging due to TTP treatment. The top five response mechanisms are listed for every dose (30 s, 60 s, and 120 s) after every time point (24 h, 48 h, and 72 h). Numbers (1–5) represent the ranking of the response mechanisms for every parameter

Top Tox List	24 h			48 h			72 h
	30 s	60 s	120 s	30 s	60 s	120 s	30 s	60 s	120 s
Nrf2-mediated oxidative stress	1	1	1		4	3	3		3
Decreases permeability transition of mitochondrial membrane	2			1			5	1
Mitochondrial dysfunction	3
Response to proteinuria-induced oxidative stress in renal proximal tubulus cells	4			2
Increases bradycardia	5			5
Renal necrosis/cell death		2	3
Aryl hydrocarbon receptor signaling		3	2
PPARα/RXRα activation		4			3			4
Increases transmembrane potential of mitochondrial membrane		5	5			4			5
Xenobiotic metabolism signaling			4
Mechanisms of gene regulation by peroxisome proliferators via PPARα				3	1	2	4
Increases renal proliferation				4
Oxidative stress					2	1	1	2	2
PXR/RXR activation					5			3
Cell cycle: G2/M DNA checkpoint regulation						5			1
TR/RXR activation							2	5
Acute renal failure panel									4