Table 1.

Medical manifestations	Associated pathophysiology
Cannabis induced arteritis [44, 45], cannabis induced posterior circulation stroke [46], and myocardial infarction [47]	This is likely due to the vasoconstrictor effect of cannabis
Chronic cough, bullous emphysema, and chronic obstructive lung disorder [48, 49]	Cannabis smoke is known to contain polycyclic aromatic hydrocarbons and other carcinogens In addition, heavy use of cannabis is likely to lead to generalized airway inflammation
Cannabis hyperemesis syndrome [50]	This seems to be a paradoxical effect associated with the usage of cannabis
Adipose tissue insulin resistance, pancreatitis [51, 52]	Proven underlying mechanisms have not been ascertained